Amble Health vs ShedRx vs TrimRx (2026)

On tirzepatide, the order is ShedRx↗ ($289) → Amble Health ($300) → TrimRx↗ ($349) — gaps of $11 and then $49 a month, a $720 spread across a year between first and last. All-in figures, 10 mg basis, captured 2026-08-09.

Updated 2026-08-10 · figures captured 2026-08-09 · how we verify

§ Each record, condensed

The three records, one screen

ShedRx: the record, condensed

ShedRx’s tirzepatide program bills $289 a month once every mandatory fee is counted, measured at the 10 mg maintenance basis. The structure is tiered: the advertised entry point is $199, but the maintenance figure — the one a full year is actually billed at — is $289. That $90 gap between the ad and the anniversary is the single most important line in this record.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

To place the number: #5 of 17 verified programs, with the floor $74/month below at NexLife↗ ($215); the approved-product yardstick (Zepbound (LillyDirect↗)) sits at $449, so the compounded case here is worth $160 a month. A year at this figure: $3,468 monthly-billed.

ShedRx’s semaglutide program bills $249 a month once every mandatory fee is counted, measured at the 2.4 mg maintenance basis. Note the shape: $175 is the number in the marketing, $249 is the number at maintenance. The $74 difference is not a fee or a trick per se — it is dose-tiered pricing doing what dose-tiered pricing does — but it means the advertised figure describes month one, not month twelve.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $249 is the whole subscription, which makes ShedRx unusually easy to compare and unusually easy to leave.

Context for that figure: it ranks #13 of 20 in the verified semaglutide index — $116/month above the floor (Oak Longevity, $133) — and sits $100 under the brand benchmark (Wegovy (NovoCare↗), $349 at maintenance). Annualized, a monthly-billed year here runs $2,988.

Operationally at ShedRx: shipping included; commitment none month-to-month; cancellation 72-hour notice before the next billing cycle; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the ShedRx page · visit ShedRx ↗

Amble Health: the record, condensed

On tirzepatide, the number that matters at Amble Health is $300 a month all-in — the figure at the 10 mg maintenance basis this whole site ranks on. It is a flat structure: 2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available) all bill identically. In a market where most low advertised prices quietly belong to the starter dose, a flat figure is the difference between a quote and a teaser.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

To place the number: #9 of 17 verified programs, with the floor $85/month below at NexLife ($215); the approved-product yardstick (Zepbound (LillyDirect)) sits at $449, so the compounded case here is worth $149 a month. A year at this figure: $3,600 monthly-billed.

Operationally at Amble Health: shipping unknown; commitment unknown; cancellation not published; pharmacy not publicly named — ask in writing before paying; states: not published; evidence third-party reported, captured 2026-08-05. The full record with source and archive links: the Amble Health page

TrimRx: the record, condensed

Start with the load-bearing figure: $349 a month, all-in, is what TrimRx charges for tirzepatide at the 10 mg basis. It is a flat structure: 2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available) all bill identically. In a market where most low advertised prices quietly belong to the starter dose, a flat figure is the difference between a quote and a teaser.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $349 is the whole subscription, which makes TrimRx unusually easy to compare and unusually easy to leave.

To place the number: #11 of 17 verified programs, with the floor $134/month below at NexLife ($215); the approved-product yardstick (Zepbound (LillyDirect)) sits at $449, so the compounded case here is worth $100 a month. A year at this figure: $4,188 monthly-billed.

Start with the load-bearing figure: $299 a month, all-in, is what TrimRx charges for semaglutide at the 2.4 mg basis. The price is dose-flat: the standard titration ladder (0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg) is financially invisible here, because the top rung bills exactly what the bottom rung billed. That converts the advertised number from a floor into a ceiling — the strongest single structural feature a program in this category can have.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $299 is the whole subscription, which makes TrimRx unusually easy to compare and unusually easy to leave.

Context for that figure: it ranks #17 of 20 in the verified semaglutide index — $166/month above the floor (Oak Longevity, $133) — and sits $50 under the brand benchmark (Wegovy (NovoCare), $349 at maintenance). Annualized, a monthly-billed year here runs $3,588.

Operationally at TrimRx: shipping included; commitment none month-to-month; cancellation check terms before prepaying; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the TrimRx page · visit TrimRx ↗

§ The three-way read

Prices, gaps, and what sits inside them

ShedRx holds the low ground at $289 with no membership attached. Amble Health follows at $300 (+$11/mo, $132/yr). TrimRx tops the trio at $349 (+$60/mo over the leader, $720/yr) — note its record’s watch-out below.

The semaglutide picture reshuffles nothing: ShedRx $249 → TrimRx $299 — a reminder that molecule choice and provider choice are separate decisions, priced separately in the semaglutide index.

§ Category winners among the three

Who wins what

Cheapest month-to-month: ShedRx ($289); cheapest 12-month path: ShedRx ($3,468); dose-flat structure: Amble Health and TrimRx; cheapest semaglutide of the three: ShedRx ($249).

Every winner above is a computation, not a placement; the pairwise pages carry the full duels: ShedRx vs Amble Health (record · record) · ShedRx vs TrimRx · Amble Health vs TrimRx (record · record).

§ Structure, three ways

Everything besides the three prices

Memberships: ShedRx none; Amble Health none; TrimRx none. Structures: ShedRx step/tiered; Amble Health dose-flat; TrimRx dose-flat. Pharmacies: ShedRx not named; Amble Health not named; TrimRx not named. States: ShedRx — not published; Amble Health — not published; TrimRx — not published. Exit terms: ShedRx — 72-hour notice before the next billing cycle; Amble Health — not published; TrimRx — check terms before prepaying.

The census reading: where all three match on an axis, that axis cannot break the tie and the price column rules; where they split — a membership here, an unnamed pharmacy there — the split is usually worth more than a small price gap, because structure is what you live with after month one. Evidence for all three: ShedRx source-verified (2026-08-05); Amble Health third-party reported (2026-08-05); TrimRx source-verified (2026-08-05).

The trio on semaglutide, across time

3 mo: ShedRx $747 vs TrimRx $897 6 mo: ShedRx $1,494 vs TrimRx $1,794 12 mo: ShedRx $2,988 vs TrimRx $3,588 — monthly-billed totals; prepaid paths where published appear on each provider page.

§ Twelve and twenty-four months

The trio, annualized

ShedRx: $3,468/yr monthly-billed; Amble Health: $3,600/yr monthly-billed; TrimRx: $4,188/yr monthly-billed. Across two years at monthly billing the first-to-last spread widens to $1,440 — the horizon at which structure (prepaid ladders, flat pricing, membership drag) matters more than the sticker.

The elimination read

A three-way choice is really two eliminations, so run them in order. Eliminate TrimRx first unless it names its edge: at $349 it carries a $60/month premium over the floor of this trio — $720 a year, about 2.5 extra months of therapy at ShedRx’s rate — and a premium that size must point at a specific line in its record (its particular program design) or it is decoration. Then interrogate Amble Health’s middle ground: its dose-flat structure removes titration repricing; if that specific thing is on your personal ledger, the $11/month over the floor can be rational — if not, the middle is where budgets go to leak. What survives is ShedRx at $289, which wins by default rather than by argument — exactly how a price index should crown things — subject to the two checks no ranking can run for you: your state at intake, and your prescriber on the medication itself.

The same trio on best published rate: ShedRx $289 → Amble Health $300 → TrimRx $349 — all three price month-to-month only at capture. Short-horizon totals, monthly-billed: 3 months — ShedRx $867, Amble Health $900, TrimRx $1,047; 6 months — ShedRx $1,734, Amble Health $1,800, TrimRx $2,094. 0 of the three publish a prepaid path below their own monthly billing; the twelve- and twenty-four-month table below carries those, labeled.

The record-quality read, scored on the five checkable disclosures this index tracks (maintenance price, named pharmacy, published states, published cancellation terms, source-verified capture): ShedRx 4/5, Amble Health 3/5, TrimRx 4/5. ShedRx discloses the most and Amble Health the least, and in this market disclosure predicts disclosure — the axis where a program goes quiet is reliably where its checkout surprises live. The three match on every disclosure axis, which is rare and worth noting in their favor collectively. Scores recompute from the public records like everything else here.

Read as a decision: start from ShedRx and make the other two argue upward. Amble Health’s case is its structure; TrimRx’s case must be worth $720 a year in named features — the honest unit being months of medication (2.5 of them at the floor rate). The pairwise pages above hold each argument in full, and the calculator holds your version of it.