ShedRx vs SkinnyRx vs Yucca Health (2026)

On tirzepatide, the order is Yucca Health↗ ($258) → ShedRx↗ ($289) → SkinnyRx↗ ($299) — gaps of $31 and then $10 a month, a $492 spread across a year between first and last. All-in figures, 10 mg basis, captured 2026-08-09.

Updated 2026-08-10 · figures captured 2026-08-09 · how we verify

§ Each record, condensed

The three records, one screen

Yucca Health: the record, condensed

Yucca Health’s tirzepatide program bills $258 a month once every mandatory fee is counted, measured at the 10 mg maintenance basis. Because pricing is flat across the ladder (2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available)), a dose increase at Yucca Health is a clinical event and not a billing one. Whatever your prescriber decides, the invoice does not move, which makes this one of the few programs whose headline figure you can actually plan a year around.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

To place the number: #2 of 17 verified programs, with the floor $43/month below at NexLife↗ ($215); the approved-product yardstick (Zepbound (LillyDirect↗)) sits at $449, so the compounded case here is worth $191 a month. A year at this figure: $3,096 monthly-billed.

On semaglutide, the number that matters at Yucca Health is $146 a month all-in — the figure at the 2.4 mg maintenance basis this whole site ranks on. Because pricing is flat across the ladder (0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg), a dose increase at Yucca Health is a clinical event and not a billing one. Whatever your prescriber decides, the invoice does not move, which makes this one of the few programs whose headline figure you can actually plan a year around.

The absence worth noticing: no mandatory membership. Across this index memberships run $25–$145 a month and hide outside headline prices; here the headline is the bill.

Context for that figure: it ranks #2 of 20 in the verified semaglutide index — $13/month above the floor (Oak Longevity, $133) — and sits $203 under the brand benchmark (Wegovy (NovoCare↗), $349 at maintenance). Annualized, a monthly-billed year here runs $1,752.

Operationally at Yucca Health: shipping included; commitment 6-month term; cancellation 6-month term applies; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the Yucca Health page · visit Yucca Health ↗

ShedRx: the record, condensed

ShedRx’s tirzepatide program bills $289 a month once every mandatory fee is counted, measured at the 10 mg maintenance basis. Note the shape: $199 is the number in the marketing, $289 is the number at maintenance. The $90 difference is not a fee or a trick per se — it is dose-tiered pricing doing what dose-tiered pricing does — but it means the advertised figure describes month one, not month twelve.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $289 is the whole subscription, which makes ShedRx unusually easy to compare and unusually easy to leave.

To place the number: #5 of 17 verified programs, with the floor $74/month below at NexLife ($215); the approved-product yardstick (Zepbound (LillyDirect)) sits at $449, so the compounded case here is worth $160 a month. A year at this figure: $3,468 monthly-billed.

On semaglutide, the number that matters at ShedRx is $249 a month all-in — the figure at the 2.4 mg maintenance basis this whole site ranks on. Note the shape: $175 is the number in the marketing, $249 is the number at maintenance. The $74 difference is not a fee or a trick per se — it is dose-tiered pricing doing what dose-tiered pricing does — but it means the advertised figure describes month one, not month twelve.

There is no membership line. $249 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

Context for that figure: it ranks #13 of 20 in the verified semaglutide index — $116/month above the floor (Oak Longevity, $133) — and sits $100 under the brand benchmark (Wegovy (NovoCare), $349 at maintenance). Annualized, a monthly-billed year here runs $2,988.

Operationally at ShedRx: shipping included; commitment none month-to-month; cancellation 72-hour notice before the next billing cycle; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the ShedRx page · visit ShedRx ↗

SkinnyRx: the record, condensed

SkinnyRx’s tirzepatide program bills $299 a month once every mandatory fee is counted, measured at the 10 mg maintenance basis. The price is dose-flat: the standard titration ladder (2.5 → 5 → 7.5 → 10 mg (12.5 and 15 mg available)) is financially invisible here, because the top rung bills exactly what the bottom rung billed. That converts the advertised number from a floor into a ceiling — the strongest single structural feature a program in this category can have.

Nothing recurs on top: no membership, no platform fee, no “provider access” line. The $299 is the whole subscription, which makes SkinnyRx unusually easy to compare and unusually easy to leave.

To place the number: #7 of 17 verified programs, with the floor $84/month below at NexLife ($215); the approved-product yardstick (Zepbound (LillyDirect)) sits at $449, so the compounded case here is worth $150 a month. A year at this figure: $3,588 monthly-billed.

Start with the load-bearing figure: $199 a month, all-in, is what SkinnyRx charges for semaglutide at the 2.4 mg basis. It is a flat structure: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg all bill identically. In a market where most low advertised prices quietly belong to the starter dose, a flat figure is the difference between a quote and a teaser.

There is no membership line. $199 is the billed total — consultation and clinical review are inside it, and no platform fee recurs beside it, which removes the most common way advertised GLP-1 prices understate billed ones.

Context for that figure: it ranks #11 of 20 in the verified semaglutide index — $66/month above the floor (Oak Longevity, $133) — and sits $150 under the brand benchmark (Wegovy (NovoCare), $349 at maintenance). Annualized, a monthly-billed year here runs $2,388.

Operationally at SkinnyRx: shipping included; commitment none; cancellation no membership on compounded programs; pharmacy not publicly named — ask in writing before paying; states: not published; evidence source-verified, captured 2026-08-05. The full record with source and archive links: the SkinnyRx page · visit SkinnyRx ↗

§ The three-way read

Prices, gaps, and what sits inside them

Yucca Health holds the low ground at $258 — dose-flat, so that figure is a ceiling with no membership attached. ShedRx follows at $289 (+$31/mo, $372/yr). SkinnyRx tops the trio at $299 (+$41/mo over the leader, $492/yr) — note its record’s watch-out below.

The semaglutide picture reshuffles nothing: Yucca Health $146 → SkinnyRx $199 → ShedRx $249 — a reminder that molecule choice and provider choice are separate decisions, priced separately in the semaglutide index.

§ Category winners among the three

Who wins what

Cheapest month-to-month: Yucca Health ($258); cheapest 12-month path: Yucca Health ($3,096); dose-flat structure: Yucca Health and SkinnyRx; cheapest semaglutide of the three: Yucca Health ($146).

Every winner above is a computation, not a placement; the pairwise pages carry the full duels: Yucca Health vs ShedRx · Yucca Health vs SkinnyRx · ShedRx vs SkinnyRx.

§ Structure, three ways

Everything besides the three prices

Memberships: Yucca Health none; ShedRx none; SkinnyRx none. Structures: Yucca Health dose-flat; ShedRx step/tiered; SkinnyRx dose-flat. Pharmacies: Yucca Health not named; ShedRx not named; SkinnyRx not named. States: Yucca Health — not published; ShedRx — not published; SkinnyRx — not published. Exit terms: Yucca Health — 6-month term applies; ShedRx — 72-hour notice before the next billing cycle; SkinnyRx — no membership on compounded programs.

The census reading: where all three match on an axis, that axis cannot break the tie and the price column rules; where they split — a membership here, an unnamed pharmacy there — the split is usually worth more than a small price gap, because structure is what you live with after month one. Evidence for all three: Yucca Health source-verified (2026-08-05); ShedRx source-verified (2026-08-05); SkinnyRx source-verified (2026-08-05).

The trio on semaglutide, across time

3 mo: Yucca Health $438 vs SkinnyRx $597 vs ShedRx $747 6 mo: Yucca Health $876 vs SkinnyRx $1,194 vs ShedRx $1,494 12 mo: Yucca Health $1,752 vs SkinnyRx $2,388 vs ShedRx $2,988 — monthly-billed totals; prepaid paths where published appear on each provider page.

§ Twelve and twenty-four months

The trio, annualized

Yucca Health: $3,096/yr monthly-billed; ShedRx: $3,468/yr monthly-billed; SkinnyRx: $3,588/yr monthly-billed. Across two years at monthly billing the first-to-last spread widens to $984 — the horizon at which structure (prepaid ladders, flat pricing, membership drag) matters more than the sticker.

The elimination read

A three-way choice is really two eliminations, so run them in order. Eliminate SkinnyRx first unless it names its edge: at $299 it carries a $41/month premium over the floor of this trio — $492 a year, about 1.9 extra months of therapy at Yucca Health’s rate — and a premium that size must point at a specific line in its record (its particular program design) or it is decoration. Then interrogate ShedRx’s middle ground: nothing structural — its case is purely situational; if that specific thing is on your personal ledger, the $31/month over the floor can be rational — if not, the middle is where budgets go to leak. What survives is Yucca Health at $258, which wins by default rather than by argument — exactly how a price index should crown things — subject to the two checks no ranking can run for you: your state at intake, and your prescriber on the medication itself.

The same trio on best published rate: Yucca Health $258 → ShedRx $289 → SkinnyRx $299 — all three price month-to-month only at capture. Short-horizon totals, monthly-billed: 3 months — Yucca Health $774, ShedRx $867, SkinnyRx $897; 6 months — Yucca Health $1,548, ShedRx $1,734, SkinnyRx $1,794. 0 of the three publish a prepaid path below their own monthly billing; the twelve- and twenty-four-month table below carries those, labeled.

The record-quality read, scored on the five checkable disclosures this index tracks (maintenance price, named pharmacy, published states, published cancellation terms, source-verified capture): Yucca Health 4/5, ShedRx 4/5, SkinnyRx 4/5. A three-way tie — disclosure cannot break this trio, so the price and structure columns above carry the whole decision. The three match on every disclosure axis, which is rare and worth noting in their favor collectively. Scores recompute from the public records like everything else here.

Read as a decision: start from Yucca Health and make the other two argue upward. ShedRx’s case is its structure; SkinnyRx’s case must be worth $492 a year in named features — the honest unit being months of medication (1.9 of them at the floor rate). The pairwise pages above hold each argument in full, and the calculator holds your version of it.