The two molecules behind every program
This market is two medications wearing forty storefronts. Tirzepatide — the stronger trial averages, the higher prices (brand $299–$449, compounded from $215) — carries about 60% of the category's search interest and 60% of this site. Semaglutide — cheaper everywhere (brand $349, compounded from $133), with the only approved oral option (from $149).
Updated 2026-08-10 · figures captured 2026-08-09 · how we verify
Tirzepatide
Zepbound & Mounjaro; SURMOUNT evidence; the $215–$597 compounded market; the 503A lane.
$215+
Semaglutide
Wegovy, Ozempic, the oral pill; the shrinking compounded discount; the safety question sorted.
$133+
Head-to-head, in the only randomized comparison that matters (SURMOUNT-5, NEJM 2025): tirzepatide averaged roughly 20% body-weight reduction versus semaglutide's 14% at maximum tolerated doses — about 47% greater relative loss — at a real price premium at every layer of the market. Whether that trade is worth it for you is a clinical and financial question in that order: prescriber first, then the cost answer and your own math.